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| Cancer News |
 Januar 2010 Volume 12, Number 1 |
Cover Illustration: The cover image is an artistic depiction of the results from the paper by Zillhardt et.al. wherein c-Met inhibition using a small molecule is shown to reduce tumor burden and metastasis in a mouse model. |
TABLE OF CONTENTS
Research Article |
| An orally available small molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a Pre-clinical model of ovarian cancer metastasis |
| Marion Zillhardt, James G Christensen and Ernst Lengyel |
| Abstract Full Article |
| Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma. |
| Amanda G S Silva, Alexander Graves, Amanda Guffei, Tatiana i Ricca, Renato A Mortara, Miriam G Jasiulionis and Sabine Mai |
| Abstract Full Article |
| Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma |
| Yukiko Nakahara, Paul A Northcott, Meihua Li, Paul N Kongkham, Christian Smith, Hai Yan, Sidney Croul, Young-Shin Ra, Charles Eberhart, Annie Huang, Darrell Bigner, Wesia Grajkowska, Timothy Van Meter, James T Rutka and Michael Taylor |
| Abstract Full Article |
| INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support |
| Jun Li, Margaret Favata, Jennifer A. Kelley, Eian Caulder, Beth Thomas, Xiaoming Wen, Richard B Sparks, Ari Arvanitis, James D. Rogers, Andrew P Combs, Kris Vaddi, Kimberly A Solomon, Peggy Scherle, Robert Newton and Jordan S Fridman |
| Abstract Full Article |
| A novel small molecule, LLL12 inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in human cancer cells |
| Li Lin, Brian Hutzen, Pui-Kai Li, Sarah Ball, Mingxin Zuo, Stephanie DeAngelis, Elizabeth Foust, Matthew Sobo, Lauren Friedman, Deepak Bhasin, Ling Cen, Chenglong Li and Jiayuh Lin |
| Abstract Full Article |
| Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: The role of gonadotropins |
| Yael Tzuman, Stav Sapoznik, Dorit Granot, Nava Nevo and Michal Neeman |
| Abstract Full Article |
| Regulation of G1 arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2á phosphorylation |
| Yan Liu, Csaba Laszlo, Yi Liu , Wei Liu, Xiaozhuo Chen, Susan C Evans and Shiyong Wu |
| Abstract Full Article |
| Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cells |
| Delphine Lamoral-Theys, Marie Le Mercier, Benjamin le Calve, Michal A Rynkowski, Céline Bruyère, Christine Deacestecker, Benjamin Haibe-Kains, Gianluca Bontempi, Jacques Dubois, Florence Lefranc and Robert Kiss |
| Abstract Full Article |
| Activation of the unfolded protein response (UPR) contributes towards the anti-tumor activity of the histone deacetylase (HDAC) inhibitor vorinostat. |
| Soumen Kahali, Bhaswati Sarcar, Bin Fang, Eli S Williams, John M Koomen, Philip J Tofilon and Prakash Chinnaiyan |
| Abstract Full Article |
| Late release of circulating endothelial cells and endothelial progenitor cells after chemotherapy predicts response and survival in cancer patients |
| J M Roodhart, Marlies H Langenberg, Joost S Vermaat, Martijn P Lolkema, Arnold Baars, Rachel H Giles, Els O Witteveen and Emile E Voest |
| Abstract Full Article |
| Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice |
| Balaiya Velmurugan, Rana P. Singh, Nidhi Kaul, Rajesh Agarwal and Chapla Agarwal |
| Abstract Full Article |
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